API R&D
Insilco Polymorph screening
Polymorph screening is crucial in pharmaceuticals and materials science to identify the optimal crystalline forms (polymorphs) of substances. Our tool simulates molecular behavior, predicting polymorphs based on factors like intermolecular interactions and thermodynamic stability. We screen polymorph against wide range of solvents at multiple temperature to characterize these forms for properties such as stability and solubility. This accelerates discovery, guiding the selection of polymorphs for further development and manufacturing, saving time and resources in material and drug development.
Insilco Saltscreening
SoluDEM stands out as the sole software capable of screening active pharmaceutical ingredients (API) against all salts.Predicts the compatibility, stability of different salt forms under various temperature conditions. Reduce the need for extensive laboratory experiments, thereby conserving time and resources.
pH and dissolution media solubility
Our model is the first of its kind in predicting solubility based on pH and biorelevant factors. It provides accurate predictions across various pH levels and different dissolution media such as gastric fluid, intestinal fluid, and simulated body fluids at multiple temperatures. This helps in gaining a comprehensive understanding of how drugs behave in terms of solubility.
Insilco Amorphous Solid Dispersion
Our advanced models simplify the process of finding the right polymer for your drug formulation. By predicting drug-polymer interactions, we help you select the most compatible polymers. Our models also optimize the API-to-polymer ratio for improved stability and dissolution. Using quantum chemistry, we can foresee potential chemical degradation, ensuring your formulation remains stable. Plus, our in-silico screening process quickly narrows down polymer options, saving you both time and resources.