Formulation R&D

Insilco compatibility studies

Our platformoffers advanced in-silico compatibility studies designed to empower formulators in pharmaceutical development. Our model helps evaluate critical interactions such as drug-drug, drug-excipient, and excipient-excipient at specific ratios and under varying temperature conditions such as 25°C/60% RH, 40°C/75% RHbefore committing to costly and time-consuming lab experiments. This capability provides predictive accuracy and customization, enabling proactive identification of potential formulation challenges. By integrating our model into your formulation strategy, you can streamline R&D processes, mitigate risks, and achieve accelerated development timelines.

PBPK modelling - Navigating Drug Dynamics for Better Health Outcomes

PBPK (Physiologically Based Pharmacokinetic) modeling is a sophisticated computational technique used in pharmacology. It simulates how drugs distribute in the body based on physiological parameters. PBPK integrates data on drug properties, physiological factors, and disease states to predict drug behavior, aiding in drug development and personalized medicine strategies.

High throughput Excipient screening

Experience the future of formulation development with FormDEM’s revolutionary virtual excipient screening technology. Our platform enables rapid screening of over 800 excipients with an API in just 8 hours, adaptable to any temperature conditions. With an exceptional 80% accuracy rate, our model sets a new benchmark in excipient evaluation, offering high-throughput screening capabilities. Evaluate excipients at 1:1 ratios and multiple weight fractions, categorized across all pharmaceutical applications for comprehensive virtual screening possibilities. Transform your formulation strategy with our models advanced virtual screening solutions. Contact us to integrate FormDEM into your formulation development workflow and achieve optimized formulation outcomes efficiently.

Insilco Stability prediction

Predict the stability of 50 formulations within just 2 days using FormDEM under any temperature conditions such as 25°C/60%RH and 45°C/75%RH. Our model significantly enhances the ability to rank-order multiple formulations with an accuracy of 75%. It helps formulators choose the most promising options for further improvement in lab, saving materials, costs and time. Additionally, our models’ precise predictions allow researchers to focus on the best candidates, streamlining the development process. The software ensures that only the best formulations proceed to the next stage, speeding up product development and optimizing resources.

Insilco Impurity control

Control specific impurities arising from formulations to enhance assay accuracy.Our model effectively identifies and mitigate potential impurities that could compromise product quality and safety standards. This software offers insights into impurity sources and recommends strategies for minimizing their impact, ensuring formulations meet industry standards. Our model also identifies excipients contributing to impurity escalation, facilitating targeted adjustments for improved formulation integrity and efficiency. Optimizing impurity control not only enhances formulation stability but also supports cost-effective material management through informed decision-making.

Skin Permeation

In recent years, combining computational modelling and in vitro testing has become a feasible method for explaining biological complexity. As computing power advances, scientists will be able to investigate incredibly challenging models in greater depth and explain highly complicated real-world data.
Skin and membrane permeation experiments comprise an important step in the development of a transdermal, topical or ophthalmic formulations or toxicological risk assessment. These models can be helpful for choosing formulation and skin permeation enhancers which supports effective permeation of API into the skin membranes.
Utilization of systematically developed skin membrane models to gain a detail insight into the role of formulation and permeation enhancers will give a digital edge to optimize the formulation towards the desired bioavailability of API.

Model validated on in vitro human and pig skin and model membranes and in vivo rat skin.

Modelling Driven Formulation Design (MDFM) For Topical and formulation development