Our Competency & Capabilities
Simulation Based Process Optimization and Trouble Shooting
- Computational Modelling on Material compatibility, Solvent Screening, Reaction Feasibility, Crystallization, Impurities Assessment & Rejection, Toxicology studies, Stability Studies.
- Packaging material selections for a given formulation.
- Absorption Modelling, Solubility Modelling, Skin Permeability Modelling.
- IVIVC (in vitro in vivo correlation) predictive modelling.
- Identification of Critical Process Parameters (CPP) , Critical Material Attributes (CMA), Critical Quality Attributes (CQA) for manufacturing needs.
- Powder discharge status and result assessment of the powder particles in chosen blending and mixer.
- Blender/Mixer size, type and geometry assessment for an agreed yield.
- Assessment of flow during tableting and appropriate tableting speed setting, and to address homogeneity & consistency issues during tableting.
- Analytics & Statistics of powder flow during the experimental process.
Simulation Based Process Development
- Design and Model Excipient Selection, Solubility and Formulation for OSD, Liquids, Topical.
- Design and Model DEM (Discrete Element Method) simulation to accurately analyze the behavior of bulk solids involved in manufacturing process.
- Design and Model CFD (Computational Fluid Dynamics ) simulations to accurately identify Crystallization stage and Isolation process operating conditions.
- Detailed study and re-design process to meet the mixing efficiency and efficacy.
- Computation and Calculations on forces acting on individual particles in mixing and blending.
- Qualitative Analysis (segregation of particles), Quantitative Analysis (flow rate of particles).
Simulation Modelling Approaches
- Computational Chemistry.
- DEM (Discrete Element Method).
- Coupling with computation fluid dynamics for two phase flow (gas/liquids).
- Combining DEM with Population Balance Model (PBM).