a. Powder Flowability: Powder flowability should be seen as the relative movement of a bulk of particles among neighboring particles and along the container wall surface. Alternatively, flowability is the ability of a powder to flow in a desired manner in a specific piece of pharmaceutical equipment used in pilot or commercial scale.
b. Particle Rheology: Particle rheology is study of particle flow. Rheology is a functional assessment with stress& strain nature of a particleacquired with complex microstructure to predict the mechanical behavior of particle(s). During the process it is important to understand the flow patterns, and the external forces which are influencing the particles
c. Shear Stress and Particle Characterization: Shear testing and powder characterization is an approach to characterize the powder and measuring powder behaviour as it transitions from no-flow to flow. This study helps in assessing powder behavior, and understanding the shear stress on particle during its flow.
d. Dead Zone identification: Dead zone formation is common issue in bulk powder mixing. These dead zones predictionsare made using advanced AI/ML & DEM technology by simulating the particle behavior, geometry of particle & blender, and establishing the physics based on powder geometry, powder rheology, and powder stress & strain.
e. Powder segregation & Agglomeration: Powder segregation and agglomeration are critical in dealing powdered materials which will impact product quality, efficiency, and other compliance. Detailed understanding on the powders, its trajectories, and particle interaction phenomenon helps in designing effective manufacturing processes